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complementarity-determining region (CDR) design

otheractivecomplementarity-determining-region-cdr-design-abe93bfc·1 events·first seen May 21, 2026

Aliases: complementarity-determining region (CDR) design

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EvoStruct protein language models E(3)-equivariant GNN CHIMERA-Bench R-Drop consistency regularization cross-attention adapter

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zCDP composition Complementary Learning Systems Creative Quality Alignment (CQA)RSICD DeltaCR LC-DP CARV RULER-CWE CODI-CRAC 2026 matched-control protocol Random Coding ROCm

Recent events (1)

5arXiv · cs.LG·May 21, 2026·source ↗

EvoStruct: Bridging Evolutionary and Structural Priors for Antibody CDR Design via Protein Language Model Adaptation

EvoStruct addresses vocabulary collapse in GNN-based antibody CDR design by combining a frozen protein language model with an E(3)-equivariant GNN through a cross-attention adapter. The method introduces progressive PLM unfreezing and R-Drop consistency regularization to recover functionally important amino acid diversity. On CHIMERA-Bench, EvoStruct improves sequence recovery by 16%, reduces perplexity by 43%, and achieves 2.3x greater amino acid diversity compared to the best GNN baselines.

Evaluation and Benchmarking Multimodal Progress EvoStruct protein language models E(3)-equivariant GNN +4 more