4arXiv cs.AI (Artificial Intelligence)·
Self-evolving LLM annotation framework for DSM-5-TR-aligned depression symptom labeling
A new arXiv preprint proposes a human-in-the-loop annotation framework for Major Depressive Disorder (MDD) that combines LLM-assisted labeling with expert verification across three stages: evidence selection, DSM-5-TR criterion analysis, and case-level synthesis. A dual-memory architecture (Example Memory and Reflection Memory) internalizes expert feedback to iteratively improve annotations without model retraining. The framework targets dataset construction for explainable AI in mental health rather than clinical diagnosis, and exports reasoning traces and edit histories for auditability. A pilot study reports improved annotation consistency and reduced manual revision effort.
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Dep-LLM: Training-free depression diagnosis framework using structured multi-factor LLM reasoning
Dep-LLM is a training-free framework for automatic depression detection from clinical interviews that uses frozen foundation LLMs without fine-tuning. The system decomposes long clinical dialogues into five thematic factors via Chain-of-Thought analysis, applies token-level entropy-based confidence modulation, and integrates multi-factor signals for final diagnosis. Evaluated on DAIC-WOZ and E-DAIC datasets, it outperforms zero-shot baselines across 21 foundation LLMs and surpasses supervised domain-specific and commercial LLMs on multiple metrics.
LLUMI: Fine-Tuning Open-Source LLMs for Mental Health Writing Assistance Using Reddit Community Feedback
LLUMI is a two-component system (a generation model and an improvement model) designed to provide mental health writing assistance using smaller open-source LLMs hosted in privacy-preserving, on-premise environments. The system leverages Reddit community endorsement signals (upvotes/downvotes) to construct preference pairs for SFT and DPO training, then further aligns outputs via human evaluation across readability, empathy, connection, actionability, and safety dimensions. Results show LLUMI achieves performance comparable to proprietary GPT-based models on linguistic and human evaluations, suggesting community-derived preference signals can substitute for expensive expert labeling in sensitive domains.
LLMs predict dementia and depression severity from clinical interview transcripts in zero-shot and feature-extraction settings
Researchers evaluate three open-weights LLMs (Mistral 3.1, DeepHermes, Qwen3) for predicting dementia and depression severity from speech transcripts of 154 German-speaking patients in standardized clinical interviews. The study introduces a new observer-based Global Depression Scale (GDS-D) and tests both zero-shot prediction and LLM-based feature extraction for Support Vector Regression. Zero-shot performs well for depression (MAE 0.60), while structured feature extraction reduces dementia assessment error by up to 35%; pause-enriched automatic transcripts match human transcription quality, suggesting viable fully-automated screening pipelines.
Fine-tuning LLMs to passively estimate depression severity from AI mental health conversations
Researchers fine-tune a Qwen3.5-27B model with a regression head to predict PHQ-9 depression severity scores directly from AI mental health app conversation transcripts, eliminating the need for explicit self-report completion. The training set of 6,283 users combines 3,111 ground-truth labels with pseudolabels generated by Claude Opus and iterative intermediate models. On a held-out test of 842 users, the best model achieves MAE=2.6, Pearson r=0.80, and AUC=0.91 at the clinical PHQ-9≥10 threshold, with AUC>0.87 across all severity thresholds. The work demonstrates a passive, continuous symptom-monitoring approach that could reduce response bias in mental health platforms.
LLM embedding spaces partially recover expert-defined symptom structure in mental health language
A new arXiv preprint investigates whether LLM embedding geometry aligns with expert-defined symptom structure in mental health language, using 28 Reddit communities as a testbed. The authors compare pretrained and fine-tuned Qwen3 embeddings (0.6B and 4B) against an expert symptom matrix via representational similarity analysis, with controls for affective, stylistic, and topic confounds. Results show measurable but level-dependent alignment: fine-tuning strengthens it at fine-grained category levels, and larger scale improves both zero-shot alignment and fine-tuning gains. The paper argues that classification accuracy alone is insufficient to validate embedding geometry against domain knowledge.
WhoSaidIt: Human-LLM Collaborative Annotation for Multilingual Speaker-Attribute Classification
This paper proposes a human-LLM collaborative re-annotation framework for stabilizing noisy multilingual speaker-attribute labels under resource constraints. LLMs surface recurring annotation rationales through iterative expert interaction, combined with disagreement-focused sampling for targeted re-annotation. The resulting WhoSaidIt dataset covers nine speaker-attribute labels across multiple languages. Benchmarking of recent LLMs reveals substantial cross-lingual annotation divergence and highlights both capabilities and limitations of LLMs in this classification task.
Automated ICD Classification of Psychiatric Diagnoses Using NLP and LLMs
This study evaluates NLP and ML approaches for automating the mapping of free-text psychiatric descriptions to ICD diagnostic codes, using a dataset of 145,513 Spanish clinical records. Methods range from classical BoW/TF-IDF representations to transformer-based embeddings including e5_large, BioLORD, and Llama-3-8B. Fine-tuned e5_large achieved the best performance with a micro-F1 of 0.866, outperforming classical methods by capturing semantic nuance and medical terminology. The work highlights challenges of long-tail label distributions and ambiguity specific to psychiatric clinical language.
Structure-Aware Code Change Labeling with LLMs via Two-Stage Taxonomy Pipeline
This paper presents a systematic study of using LLMs for taxonomy-based labeling of code diff hunks, going beyond summarization to assign structured labels capturing semantic attributes like renames, moves, and logic modifications. The authors introduce a two-stage pipeline combining diff-hunk labeling with structural refinement, using few-shot prompting to remain language-agnostic. Evaluated across four LLMs on a curated benchmark of natural and synthetic patches, the best configuration achieves 84% recall and 81% precision. Results suggest LLM-based structured labeling can complement static analysis tools in code review workflows.