Atlas H&E-TME

Atlas H&E-TME: AI system matches expert pathologist accuracy for scalable tumor microenvironment profiling

Researchers present Atlas H&E-TME, an AI system built on the Atlas family of pathology foundation models that generates over 4,500 quantitative readouts per whole-slide H&E image at cell-level resolution across multiple cancer types. The system is validated using a novel dual framework: an IHC-informed multi-pathologist consensus protocol for depth, and benchmarking against 200,000+ annotations across 1,500+ cases from 25+ sources spanning eight cancer types. Atlas H&E-TME matches or exceeds pathologist H&E-only performance, demonstrating that standard histopathology slides can serve as a scalable quantitative window into the tumor microenvironment. The work advances computational pathology by enabling tissue-based biomarker discovery without requiring specialized staining modalities.