ESMFold2

ESMFold2: The Bitter Lesson is Coming for Proteins — Alex Rives, BioHub

A Latent Space interview/commentary piece featuring Alex Rives of BioHub discussing ESMFold2 and the application of the 'bitter lesson' (scale and general methods beating hand-crafted inductive bias) to protein structure prediction and biology. The piece covers the tension between dataset scale versus domain-specific inductive bias in biological ML, and touches on world models and programmable biology. This represents a significant perspective from a leading researcher in protein language models on the next generation of biological foundation models.