The Bitter Lesson
the-bitter-lesson-2e56dfa1·2 events·first seen 29d agoAliases: The Bitter Lesson, Bitter Lesson
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The Bitter Lesson versus The Garbage Can
A commentary piece from One Useful Thing framing a tension between the 'Bitter Lesson' (scale and compute dominate) and some alternative 'Garbage Can' model of AI development, asking whether process matters in AI progress. The body is a teaser with minimal substantive content visible. The framing suggests an analysis of competing paradigms for how AI capabilities advance.
ESMFold2: The Bitter Lesson is Coming for Proteins — Alex Rives, BioHub
A Latent Space interview/commentary piece featuring Alex Rives of BioHub discussing ESMFold2 and the application of the 'bitter lesson' (scale and general methods beating hand-crafted inductive bias) to protein structure prediction and biology. The piece covers the tension between dataset scale versus domain-specific inductive bias in biological ML, and touches on world models and programmable biology. This represents a significant perspective from a leading researcher in protein language models on the next generation of biological foundation models.