robin-c965bd9e·4 events·first seen Aliases: Robin
FutureHouse, University of Oxford, and Fordham University released Robin, an open-source AI agent that autonomously identifies existing drugs that could treat a given disease by iteratively hypothesizing mechanisms, designing experiments, and ranking drug candidates using literature-search sub-agents. In a demonstration targeting dry age-related macular degeneration, Robin identified two drugs (Y-27632 and Ripasudil) that produced roughly 1.75–2x increases in RPE phagocytosis in human cell experiments. The pipeline uses GPT o4-mini for most language tasks and Claude 3.7 Sonnet for pairwise ranking, with human involvement limited to naming the disease and running lab experiments. The work represents a concrete, experimentally validated instance of agentic AI accelerating drug repurposing research.
Researchers introduce Autoregressive Boltzmann Generators (ArBG), a framework that replaces normalizing flows in Boltzmann Generators with autoregressive models inspired by LLM architectures, circumventing invertibility constraints and enabling sequential inference-time interventions. The approach demonstrates significant improvements over flow-based models across benchmarks, particularly on larger peptide systems like the 10-residue Chignolin. The authors also release Robin, a 132M-parameter transferable model trained with ArBG that reduces zero-shot energy error on 8-residue systems by over 60% compared to prior state-of-the-art.
OpenAI and Broadcom announced Jalapeño, OpenAI's first custom inference chip, designed in nine months with AI-assisted design and showing better performance-per-watt than current accelerators; engineering samples are already running GPT-5.3-Codex-Spark with datacenter deployment planned by end of 2026. Sakana AI released Fugu, a multi-agent routing system that scored 73.7% on SWE-Bench Pro, outperforming Claude Opus 4.8 and GPT-5.5 while remaining below the inaccessible Fable 5. Additional items cover Anthropic's Claude Tag Slack integration for async team collaboration, Seedance 2.5 video model improvements, the Robin autonomous biology research agent that identified a novel drug candidate, and a Getty Images licensing partnership with OpenAI.
Robin is an open-source Python tool that uses AI to perform OSINT (Open Source Intelligence) on the dark web, accumulating 5,258 GitHub stars with 109 added today. The project applies AI/ML capabilities to automated intelligence gathering from dark web sources. It represents a practical deployment of AI for cybersecurity and threat intelligence use cases.