T-cell acute lymphoblastic leukemia

Google's AlphaGenome Interprets Non-Coding DNA That Regulates Genetic Expression

Google has released AlphaGenome, an open-weights model that interprets the ~98% of human and mouse genomes that regulate gene expression rather than coding for proteins. The model takes up to 1 million DNA base pairs as input and outputs roughly 6,000 human and 1,000 mouse gene properties, using a CNN-transformer-CNN architecture trained via ensemble distillation from 64 pretrained models. Across 50 evaluations, AlphaGenome matched or exceeded prior models in 47 cases, and correctly predicted expression changes associated with T-cell acute lymphoblastic leukemia. Weights, API, and inference code are freely available for noncommercial use.