AlphaGenome
alphagenome-13b076b1·2 events·first seen 28d agoAliases: AlphaGenome
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AlphaGenome: DeepMind's Unified DNA Sequence Model for Regulatory Variant-Effect Prediction
DeepMind has introduced AlphaGenome, a new unified DNA sequence model designed to advance regulatory variant-effect prediction and improve understanding of genome function. The model is now available via API, making it accessible to researchers. AlphaGenome represents a significant step in applying large-scale AI to genomics, particularly for interpreting non-coding regulatory regions of the genome.
Google's AlphaGenome Interprets Non-Coding DNA That Regulates Genetic Expression
Google has released AlphaGenome, an open-weights model that interprets the ~98% of human and mouse genomes that regulate gene expression rather than coding for proteins. The model takes up to 1 million DNA base pairs as input and outputs roughly 6,000 human and 1,000 mouse gene properties, using a CNN-transformer-CNN architecture trained via ensemble distillation from 64 pretrained models. Across 50 evaluations, AlphaGenome matched or exceeded prior models in 47 cases, and correctly predicted expression changes associated with T-cell acute lymphoblastic leukemia. Weights, API, and inference code are freely available for noncommercial use.