ICO (Intervention, Comparator, Outcome) framework

AutoForest: End-to-End LLM System for Automated Forest Plot Generation from Biomedical Studies

AutoForest is presented as the first end-to-end system that generates publication-ready forest plots directly from biomedical papers using large language models. The system automatically suggests ICO (Intervention, Comparator, Outcome) elements, extracts outcome data, performs statistical synthesis, and renders forest plots without manual intervention. A user study with clinicians demonstrates its effectiveness on real-world examples, aiming to accelerate systematic review and meta-analysis workflows.